The Portland Trail Blazers face a significant challenge in their Western Conference road game against the San Antonio Spurs on Wednesday night, as they may have to navigate key absences. Coming off a tough overtime loss to the Denver Nuggets, the Blazers' quest to bounce back is complicated by a lengthy injury report headlined by two of their most impactful players.

Dynamic guard Shaedon Sharpe is listed as doubtful due to a stress reaction in his left fibula, an injury that has kept him sidelined since early February. While his absence is expected to continue, there is optimism that the high-flying scorer could return in time for the upcoming Play-In Tournament, offering a potential late-season boost.

Veteran forward Jerami Grant has been officially ruled out, marking his fifth consecutive game missed with a right calf strain. His two-way presence and scoring punch will be sorely missed, placing more responsibility on the shoulders of young players like Scoot Henderson, Kris Murray, and Sidy Cissoko to step up in his stead.

The injury list extends further, with franchise icon Damian Lillard (torn Achilles) remaining out and Vit Krejci listed as doubtful with a calf contusion. Facing a Spurs team also managing its own injury concerns, the Blazers' depth and adaptability will be tested in this late-season showdown. Tip-off from San Antonio is set for 9:30 p.m. ET on ESPN.