The Detroit Tigers are looking to shake off a tough Monday loss when they host the Boston Red Sox for the second game of a three-game series Tuesday night. After dropping a 5-4 decision in the opener, the Tigers (18-18) received even more bad news: two-time Cy Young winner Tarik Skubal is out indefinitely after undergoing elbow surgery. Skubal was scratched from his scheduled start Monday, and the Red Sox (14-21) pounced, racking up 12 hits—their third-highest total of the season—to win their third straight series opener.

First pitch is set for 6:40 p.m. ET at Comerica Park in Detroit, where the Tigers will send left-hander Framber Valdez (2-1, 3.35 ERA) to the mound. Valdez has been solid this season, but he’ll face a Boston lineup that’s finally showing some life. The Red Sox counter with Jovani Moran (0-0, 2.33 ERA), who will make his first MLB start after working out of the bullpen. These two teams have split their last 10 meetings, so expect a tight battle.

According to the latest MLB odds, the Tigers are -158 favorites (risk $158 to win $100), while the over/under for total runs is set at 8.5. That line suggests a moderately high-scoring game, but which side offers the best value? SportsLine’s proven computer model, which simulates every MLB game 10,000 times, has crunched the numbers for this matchup. The model is coming off a perfect 5-0 week on top-rated MLB picks and has excelled at home run prop predictions, returning nearly 30 units of profit in 2025.

After running the simulations, the model is leaning toward the Over 8.5 combined runs. With Valdez facing a Red Sox lineup that’s finding its groove and Moran making his first start, the stage is set for plenty of action. For more betting insights and the model’s full picks, check out the latest odds and analysis before Tuesday’s game.