Get ready, 49ers fans—the 2026 season is shaping up to be one for the books, and it's time to start planning your game-day gear. The NFL's full schedule drops Thursday, May 14 at 8 p.m. ET on NFL Network and ESPN2, with select games and a record-setting nine international matchups announced earlier on May 13 during "Good Morning Football."

The San Francisco 49ers are already making headlines with a historic season opener: they'll kick off the regular season on September 10 in Melbourne, Australia, against the Los Angeles Rams. That's right—the Niners are going Down Under, and you'll want to be repping your red and gold from wherever you watch.

But the international excitement doesn't stop there. The 49ers also have a game scheduled in Mexico City, with the opponent to be revealed on May 13. It's a global tour for the Bay Area squad, and it adds an extra layer of intrigue to an already stacked lineup.

Here's a breakdown of who the 49ers will face in 2026. At home in Levi's Stadium in Santa Clara, they'll host the Arizona Cardinals, Los Angeles Rams, Seattle Seahawks, Denver Broncos, Las Vegas Raiders, Miami Dolphins, Minnesota Vikings, Philadelphia Eagles, and Washington Commanders. That's a mix of division rivals and tough interconference foes that will test the team's mettle.

On the road, the Niners will travel to face the Cardinals, Seahawks, Atlanta Falcons, Dallas Cowboys, Kansas City Chiefs, Los Angeles Chargers, and New York Giants. Plus, they'll take on the Rams in Australia—a neutral-site showdown that could set the tone for the entire season.

While the full schedule with dates and times is still under wraps, this early look at the opponents gives fans plenty to chew on. Whether you're stocking up on new 49ers gear for the home games or planning a watch party for those international clashes, the 2026 season promises high stakes and even higher energy. Stay tuned for the official release, and get ready to cheer on the Niners as they chase glory on three continents.