The NFL schedule release is one of the most exciting days of the offseason, and this year, it's landing on Thursday, May 14. While we already know who the Indianapolis Colts will face in 2026, the exact order of those games remains a mystery—until leaks and the official release change that.

So, before the schedule drops, let's put on our prediction hats and guess who the Colts will line up against in their Week 1 regular-season opener.

First, we need to narrow down the field. The NFL loves to kick off the season with divisional showdowns, so let's start there. That leaves us with three potential opponents: the Jacksonville Jaguars, Tennessee Titans, and Houston Texans.

But the league also likes to hit the ground running with marquee matchups that promise drama. In recent years, Colts vs. Texans games have been nail-biters, often decided in the final minutes. That kind of intensity is perfect for a season opener.

So, I'm predicting Houston as the Colts' Week 1 opponent.

Now, where will this game be played? The Colts have enjoyed home-field advantage in Week 1 for the last three seasons. That streak feels due to end. My guess? They'll hit the road, traveling to Houston to open the season.

Week 1 opponent prediction: Colts at Houston Texans

Get your gear ready—this could be a classic AFC South battle to start the year.