Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21

3 min read
Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21 - Image 1
Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21 - Image 2
Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21 - Image 3
Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21 - Image 4

Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21

Philadelphia Phillies vs Chicago Cubs Game Preview

Philadelphia vs Chicago Prediction: Odds, recent stats, trends and best bets for April 21

Philadelphia Phillies vs Chicago Cubs Game Preview

Article image
Article image
Article image

The Chicago Cubs (13-9) won Game 1 of the four-game series with the Philadelphia Phillies, 5-1. Today is the second as both teams continue to trend in different directions.

Chicago has won six-straight games and outscored their opponents, 44-14, in that span. The Cubs are hitting .293 over the past week, ranking second with the sixth-most homers (8), but the pitching staff has been on fire with a 1.76 ERA.

Philadelphia is riding a six-game losing streak and has been outscored 42-10 during this span. The Phillies have also dropped three-straight road games. In the last week, Philadelphia ranks fourth-worst in ERA (5.73) and the second-worst batting average (.173).

Lets dive into the matchup and find a sweat or two.

We’ve got all the information and analysis you need to know ahead of the game, including the latest details on the how to catch first pitch, odds, recent team performance, player stats and of course, our predictions, picks and best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Never miss a second of the action and stay up-to-date with all the latest team statistics and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Moneyline: Chicago Cubs (-131), Philadelphia Phillies (+109)

Tuesday's pitching matchup (April 21): Jesus Luzardo vs. Shota Imanaga

2026 stats: 22.1 IP, 1-3, 7.94 ERA, 1.46 WHIP, 30 Ks, 5 BB

2026 Stats: 22.0 IP, 1-1, 2.45 ERA, 0.77 WHIP, 31 Ks, 5 BB

The Phillies’ J.T. Realmuto is hitting .280 with 14 hits, 19 total bases and one home run over 50 at-bats

The Phillies’ Alec Bohm is hitting .133 with 10 hits, 14 strikeouts and 6 walks over 75 at-bats

The Cubs’ Nico Hoerner is hitting .322 with 28 hits, 44 total bases and 21 RBIs over 87 at-bats

The Cubs’ Michael Busch is hitting .169 with 13 hits, 18 strikeouts, and 10 walks over 77 at-bats

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Phillies at Cubs

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks and predictions for tonight’s game between Phillies and Cubs

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Like this article?

Order custom jerseys for your team with free design

Related Topics

Related News

Back to All News