The Detroit Lions may have finished at the bottom of the NFC North last season, but that hasn't dimmed their star power under the lights. The NFL has scheduled the Lions for a marquee Thursday Night Football matchup in Week 2, sending them to Buffalo to face the Bills on September 17. This game will officially open the doors of the Bills' brand-new, $2.2 billion Highmark Stadium, making it a historic night for both franchises.

Prime Video, the home of Thursday Night Football, broke the news during its upfront presentations. It's the latest in a series of high-profile slots for Detroit, who played five primetime games last season, plus seven more in the late-afternoon national window and their traditional Thanksgiving Day game. The Lions are clearly a team the networks want in the spotlight.

The matchup promises fireworks. Both teams boasted top-five scoring offenses last season, with the Lions averaging 28.2 points per game and the Bills close behind at 27.9. Buffalo, led by 2024 NFL MVP Josh Allen, has been a model of consistency, posting double-digit wins every year since 2019. The last time these two met was a December 2024 shootout, with the Bills edging out a 48-42 victory. For context, that was one of only two regular-season losses for a Lions team that was decimated by defensive injuries and ultimately fell in the wild-card round.

The Lions' international schedule is also taking shape. Fox announced earlier this week that Detroit will play a November 15 game in Germany, with the opponent to be revealed on Wednesday. So, whether you're gearing up for the cold of Buffalo or the atmosphere overseas, the Lions are set for a season full of travel, challenges, and must-watch football.