The Orlando Magic's quest for a playoff berth hits a critical juncture tonight in Philadelphia, but their path just got tougher. As they prepare for a high-stakes Eastern Conference Play-In game against the 76ers, the Magic's injury report reveals potential significant absences that could reshape the matchup.

Forward Jonathan Isaac and guard Jett Howard headline the list, both officially listed as questionable. Isaac, a defensive anchor, is battling a left knee sprain that has kept him out of 20 of the team's last 21 games. His potential absence would be a major blow to Orlando's defensive schemes against a potent Philadelphia offense.

Meanwhile, Howard is dealing with a left ankle sprain and is in danger of missing his sixth straight game. If the rookie wing remains sidelined, look for Tristan da Silva to continue seeing expanded minutes off the bench, providing a different look for the Magic's second unit.

This news comes as the Magic, the East's No. 8 seed with a 45-37 record, aim to upset the 76ers on the road. A victory would secure the No. 7 seed and set up a first-round playoff series with the Boston Celtics. The availability of Isaac and Howard could be the deciding factor in whether Orlando's season continues or comes to an abrupt end in the City of Brotherly Love.

Tune in tonight at 7:30 p.m. ET on Amazon Prime Video to see how the Magic adjust their game plan and which players step up in this win-or-go-home atmosphere.