Wednesday's packed 15-game MLB slate offers a prime opportunity for prop bettors, and home run picks are heating up. SportsLine expert Jacob Fetner, who finished last season up a remarkable 50 units on his home run selections, is already building momentum this week with a 5.6-unit gain. His strategy hinges on identifying powerful matchups and favorable ballpark conditions.

Fetner is confidently returning to a hot bat for his top pick: Brandon Lowe of the Pirates. Lowe has been on an absolute tear, homering in both Monday's and Tuesday's games against the Nationals, bringing his total to four home runs in his last three contests. The analytics strongly support another big swing, as Lowe boasts a .286 average and a .921 OPS against right-handed pitching over the past year, with 32 of his 38 homers coming off righties. With odds sitting at +401, Fetner sees tremendous value in backing Lowe to go deep once again.

Another compelling play centers on the Angels' Mickey Moniak. Fetner highlights Moniak's pronounced success against right-handed pitchers, against whom he has a .277 average and .870 OPS, with 28 of his 29 career homers. He's carrying that power into this season, with five of his nine hits so far leaving the yard. He'll face the Astros' Spencer Arrighetti, who is making his first start of 2025 after a tough rookie campaign. Factor in a hitter-friendly park rating (HR Index 8/10), and Moniak at +323 presents a strong opportunity.

For those looking for a high-reward longshot, Fetner points to Spencer Horwitz. The Blue Jays' batter will face Nationals starter Jake Irvin, who has surrendered the most home runs in the majors since last season. Horwitz hits righties well (.277 average, .791 OPS) and Irvin has been particularly vulnerable to left-handed power, giving up 28 of his 41 homers to lefties over the past year. At odds of +1040, this matchup offers significant upside for a potential big fly.