The 2026 NFL schedule is officially here, and it's already shaping up to be a season for the ages. From a Wednesday night kickoff to a record-breaking nine international games, plus a loaded Thanksgiving and Christmas lineup, there's no shortage of excitement. But for savvy bettors, Week 1 is where the real action begins—and where early line value can make all the difference.
At DraftKings, only four of the 16 opening-weekend matchups feature spreads greater than 3.5 points. That means we're looking at a slate full of tight, high-stakes battles. The key is knowing when to strike. Some games offer the best value right now, before months of analysis and market movement shift the lines. Others are worth waiting on. Let's break down where your early money should go.
Rams vs. 49ers: Lock in the Rams early
The Los Angeles Rams are expected to sit atop most power rankings heading into the season—even without major draft moves. San Francisco, meanwhile, faces an uphill climb. The 49ers added receivers this offseason, but the Rams countered by upgrading at cornerback. And with George Kittle sidelined after tearing his Achilles in the playoffs, the 49ers' offense loses its biggest weapon. Even if San Francisco finds some success, expect the Rams to win by at least a field goal. The early line sits at Rams -2.5, but don't be surprised if it climbs to -3 before kickoff. Grab it now.
Texans vs. Bills: Back Houston at home
Buffalo enters Week 1 with a new head coach and a revamped defensive scheme—two factors that typically require time to gel. Last season, the Texans' defense gave Josh Allen fits, and Houston walked away with a 23-19 win (boosted by a Bills kickoff return touchdown). That game saw Buffalo favored by six with Davis Mills under center for Houston. This time, the Texans should be the favorites. Play the Texans money line up to -115 while the value is still there.
Jaguars vs. [Opponent]: Jump on Jacksonville at -7
The Jaguars are currently listed as a flat 7-point favorite at DraftKings—a number that feels too good to pass up. Jacksonville was one of the AFC's top teams last season, finishing in the top eight in scoring efficiency. If the line drops even lower, double down. This is a squad that's built to cover, and early action suggests the market might be undervaluing them.
Whether you're betting now or waiting for next week's moves, keep an eye on Patrick Mahomes and the Chiefs—they're always a wildcard. But for immediate value, these three games offer the clearest path to early-season profit. Get your gear ready and your bets placed. Week 1 is closer than you think.