Dodgers vs Giants Prediction: Odds, recent stats, trends, and best bets for April 22

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Dodgers vs Giants Prediction: Odds, recent stats, trends, and best bets for April 22

Los Angeles at San Francisco Giants Game Preview

Dodgers vs Giants Prediction: Odds, recent stats, trends, and best bets for April 22

Los Angeles at San Francisco Giants Game Preview

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The San Francisco Giants (10-13) took Game 1 of its series, 3-1, versus the Los Angeles Dodgers (16-7). Los Angeles is now 1-3 over the last four games.

San Francisco is now 4-1 in the past five games and heating up. The Giants are batting .278 over the last seven days, which ranks fifth-best and the pitching staff fourth with a 2.49 ERA. San Francisco has outscored its opponents 23-15 over the last five games.

Los Angeles still ranks atop of the MLB in batting average (.298) over the last five games despite being 2-3 in that span. The Dodgers amid their worst losing skid of the season and a chance for their first series loss. Los Angeles is 2-1 on the season with Shohei Ohtani pitching and scored 15 combined runs in those three games.

Let’s dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Moneyline: Los Angeles Dodgers (-207), San Francisco Giants (+169)

Wednesday's pitching matchup (April 22): Shohei Ohtani vs. Tyler Mahle

2026 stats: 18.0 IP, 2-0, 0.50 ERA, 0.72 WHIP, 18 Ks, 6 BB

2026 Stats: 18.2 IP, 0-3, 7.23 ERA, 1.93 WHIP, 21 Ks, 12 BB

The Giants’ Luis Arraez is hitting .302 with 26 hits and 31 total bases over 86 at-bats

The Giants’ Harrison Bader is hitting .115 with 6 hits and 17 strikeouts over 52 at-bats

The Dodgers’ Andy Pages is hitting .366 with 30 hits and 49 total bases over 82 at-bats

The Dodgers’ Alex Freeland is hitting .207 with 12 hits and 22 strikeouts over 58 at-bats

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Dodgers at Giants

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Dodgers and the Giants

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