The Indianapolis Colts are facing a gauntlet to open the 2026 NFL season, and for a team that's made a habit of late-season drama, getting off to a strong start will be critical. While only two of their first five opponents made the playoffs last year, don't let that stat fool you—this stretch is loaded with elite talent and tricky circumstances.

It all kicks off in Week 1 against Lamar Jackson and the Baltimore Ravens, followed by a Week 2 showdown with Patrick Mahomes and the Kansas City Chiefs. Both teams missed the postseason in 2025, but when you're lining up against two of the league's most dynamic quarterbacks back-to-back, there's no such thing as an easy game. The Colts' defense will need to be sharp from the jump.

Week 3 brings a divisional clash with the Houston Texans, who boast one of the NFL's most disruptive defenses. On the other side of the ball, C.J. Stroud and Nico Collins form a dangerous duo that can exploit any secondary. This game could set the tone for the AFC South race.

Then comes the wildcard: a Week 4 trip to London to face the Washington Commanders. Washington had a down year in 2025, but that was largely due to Jayden Daniels missing significant time. If he's healthy, they're a different team. Plus, the transatlantic travel and unfamiliar surroundings add an extra layer of unpredictability.

To make matters tougher, the Colts don't get a bye week after their London excursion. Instead, they'll fly back and hit the road again in Week 5 to face the Pittsburgh Steelers and their formidable defense. That's three road games in the first five weeks, with no break in sight.

For a franchise that has often found itself playing catch-up late in the season, digging an early hole is the last thing they need. Every game in this opening stretch will test their resilience, depth, and ability to adapt. If the Colts can survive this gauntlet with a winning record, they'll be in prime position for the rest of the season.