The Boston Celtics and Philadelphia 76ers are set for a pivotal Game 6 on Thursday night, with the Celtics holding a 3-2 series lead after the 76ers staved off elimination with a dominant 119-97 win in Boston. Now, the series shifts back to Philadelphia, where the Celtics have already won Games 3 and 4, and where Boston boasts a strong 28-15 road record compared to the 76ers' 23-20 home mark. Tip-off from Xfinity Mobile Arena is scheduled for 8 p.m. ET.

According to the latest NBA odds from FanDuel Sportsbook, Boston enters as a 6.5-point favorite, with the moneyline sitting at -246 for the Celtics. The over/under for total points is set at 212.5, the lowest total of the series so far—a notable shift given that the Under has hit in four of the five games. For context, these teams averaged 229.6 points per game during the regular season, and many of those contests featured both Joel Embiid and Jayson Tatum. The lower total suggests oddsmakers expect a tighter, more defensive battle.

The SportsLine Projection Model, which simulates every NBA game 10,000 times, has been on a hot streak, entering the second week of the 2026 playoffs with a 25-9 record (74%) on top-rated spread picks this season. After running its simulations for Celtics vs. 76ers, the model is leaning toward the Over on the total of 212.5. While the Under has been the trend in this series, the model sees value in the Over given the offensive firepower on both sides and the fact that this total is significantly lower than the regular-season average between these two teams.

For betting enthusiasts, this Game 6 offers a fascinating contrast: a Celtics team that has been dominant on the road versus a 76ers squad fighting for survival in front of their home crowd. With the series on the line, expect intensity and drama from the opening tip.