Mark your calendars, Bills Mafia—the 2026 NFL schedule is about to drop, and Buffalo fans have plenty to get excited about. The league will unveil the full week-by-week slate for all 32 teams on Thursday, May 14, with the Buffalo Bills' complete schedule leading the conversation for a fanbase hungry for another deep playoff run.
While the full schedule remains under wraps, a few key dates have already leaked out, giving us a tantalizing preview of what's to come. The Bills are set to host the Detroit Lions in a Thursday night showdown on September 17 at 8 p.m. ET, exclusively on Amazon Prime Video. This early-season clash promises to be a heavyweight battle between two rising AFC and NFC contenders.
As we wait for the remaining weeks to be announced, here's what we know so far about the Bills' 2026 campaign:
Week 1: TBD
Week 2: vs. Detroit Lions (Thursday, Sept. 17, 8 p.m. ET, Amazon)
Weeks 3-18: To be announced Thursday, May 14
The primetime and holiday games have already started trickling out, and with the Bills' recent success, expect more marquee matchups to follow. Whether you're gearing up for a snowy December game at Highmark Stadium or planning a road trip to see Josh Allen light up a new city, this schedule release is your first step toward planning the perfect game day.
Stay tuned—we'll update this page as each week's opponent, time, and TV network are confirmed. In the meantime, get your Bills gear ready and start counting down the days until kickoff.