Amazon Prime Video has secured a blockbuster matchup to kick off its 2026 Thursday Night Football season—and it comes with a historic twist. The Week 2 game on September 17 will feature the Detroit Lions visiting the Buffalo Bills, marking the first-ever game at the Bills' brand-new Highmark Stadium in Orchard Park, New York.

Announced during Amazon's upfront presentation on Monday night, this showdown isn't just about opening a state-of-the-art venue. It's also a clash between two teams expected to be Super Bowl LXI contenders, adding serious stakes to the primetime spotlight. The last time these two met, Josh Allen and the Bills edged out a wild 48-42 shootout in Detroit on December 15, 2024—a game that had fans on the edge of their seats.

The excitement around this game goes beyond the field. Amazon's TNF coverage will feature a traveling pregame and postgame show hosted by Charissa Thompson, Ryan Fitzpatrick, and Andrew Whitworth, with Richard Sherman and Tony Gonzalez adding analysis. Fitzpatrick, a former Bills quarterback, helped deliver the news live from New York City, and the energy of Bills Mafia combined with a new stadium debut promises an electric atmosphere for Prime Video's crew in Orchard Park.

In the broadcast booth, Al Michaels and Kirk Herbstreit will return for another season of Thursday night action, bringing their signature blend of play-by-play and insight to this marquee matchup.

The 2026 NFL season kicks off on Wednesday, September 9, with the defending champion Seattle Seahawks hosting an unknown opponent on NBC. Then, on Thursday, September 11, the Los Angeles Rams and San Francisco 49ers will make history with the first-ever NFL game in Australia, airing on Netflix. The full 2026 schedule drops on Thursday, May 14, but this Lions-Bills opener is already shaping up to be a must-watch event for football fans everywhere.