The intensity of a classic NBA rivalry is reaching new heights as the Philadelphia 76ers and New York Knicks clash in the second round of the 2026 Eastern Conference Playoffs. After a lopsided 137-98 victory in Game 1, the Knicks look to build on their momentum at Madison Square Garden for Game 2 on Wednesday night at 7 p.m. ET.

Jalen Brunson and the Knicks enter as clear favorites, especially with the news that 76ers star Joel Embiid has been ruled out due to hip and ankle injuries. Without their anchor, the Sixers will rely heavily on the explosive scoring of Tyrese Maxey to keep the series competitive. The teams split their four regular-season meetings, with each squad dominating on home court—a trend the Knicks hope to continue.

Betting lines have shifted significantly following the Embiid announcement. After opening at -6.5, New York is now a -10.5 favorite, according to FanDuel Sportsbook. The over/under for total points sits at 213.5, a number that might feel low after Game 1's offensive explosion. However, oddsmakers expect a tighter contest this time around.

For those looking to make informed picks, the SportsLine Projection Model has simulated this matchup 10,000 times. Known for its sharp accuracy, the model has returned over $10,000 in profit for $100 bettors on top-rated NBA picks over the past eight-plus seasons. It enters the second round on a remarkable 26-9 run (74%) on spread picks this season.

After running the numbers, the model's analysis leans toward the Over on the 213.5 total. While it's unlikely the Knicks replicate their near-140-point performance from Game 1, the model sees enough offensive firepower on both sides to push the score past the mark. With the 76ers fighting to avoid a 2-0 hole and the Knicks looking to seize control, expect a high-energy, fast-paced battle under the bright lights of MSG.