The 2026 NFL schedule release is finally here, and while the full slate drops tonight, we already have some blockbuster matchups—and the early betting lines to go with them. Get ready for a season packed with international games, holiday classics, and a Super Bowl rematch right out of the gate.
The action kicks off Wednesday, Sept. 9, when the Seattle Seahawks host the New England Patriots in a Super Bowl LX rematch. Seattle enters as a 4.5-point favorite, setting the stage for a thrilling opener.
This season features a record nine international games, including the NFL's first-ever game in Australia. The San Francisco 49ers and Los Angeles Rams will face off in Melbourne on Thursday, Sept. 10 at 8:35 p.m. ET, with the Rams listed as 2.5-point favorites. Other international stops include Rio de Janeiro, London, Paris, Madrid, Munich, and Mexico City—truly a global season.
Thanksgiving football will be highlighted by a marquee clash between Josh Allen's Buffalo Bills and Patrick Mahomes' Kansas City Chiefs. The Bills are 2.5-point home favorites in what promises to be a prime-time thriller. And for the first time ever, fans can enjoy a Thanksgiving Eve game, featuring the Green Bay Packers vs. the Los Angeles Rams.
Here are the confirmed odds for every game we know so far (spread listed first, total in parentheses):
New England Patriots at Seattle Seahawks (-4.5, 45.5)
San Francisco 49ers vs. Los Angeles Rams (-2.5, 49.5) in Melbourne, Australia
Baltimore Ravens (-2.5, 50.5) at Dallas Cowboys in Rio de Janeiro, Brazil
Indianapolis Colts at Washington Commanders (-1.5, 48.5) in London, England
Philadelphia Eagles (-2.5, 44.5) vs. Jacksonville Jaguars in London, England
Houston Texans (-1.5, 41.5) vs. Jacksonville Jaguars in London, England
Pittsburgh Steelers at New Orleans Saints (-2.5, 42.5) in Paris, France
Cincinnati Bengals (-4.5, 48.5) vs. Atlanta Falcons in Madrid, Spain
New England Patriots at Detroit Lions (-1.5, 48.5) in Munich, Germany
Minnesota Vikings at San Francisco 49ers (-3.5, 46.5) in Mexico City, Mexico
Whether you're tracking betting lines or just planning your game-day gear, the 2026 season is shaping up to be one for the ages. Stay tuned for the full schedule release tonight!